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首頁 > 產(chǎn)品中心 > 細胞生物學 > 重組蛋白 > abs04203FGF-23 （C-6His）（10ug）

FGF-23 （C-6His）（10ug）

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  • 產(chǎn)品型號：abs04203
  • 廠商性質(zhì)：生產(chǎn)廠家
  • 更新時間：2024-07-08
  • 訪  問  量：876

詳細介紹

品牌absin貨號abs04203
規(guī)格10ug供貨周期一周
概述
描述Recombinant Human Fibroblast Growth Factor 23 is produced by our Mammalian expression system and the target gene encoding Tyr25-Ile251 is expressed with a 6His tag at the C-terminus.
別名Fibroblast Growth Factor 23, FGF-23, Phosphatonin, Tumor-Derived Hypophosphatemia-Inducing Factor, FGF23, HYPF
形態(tài)Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl,1mM EDTA,2mMDTT,pH7.4.
來源Human Cells
氨基酸序列YPNASPLLGSSWGGLIHLYTATARNSYHLQIHKNGHVDGAPHQTIYSALMIRSEDAGFVVITGVM SRRYLCMDFRGNIFGSHYFDPENCRFQHQTLENGYDVYHSPQYHFLVSLGRAKRAFLPGMNPPPY SQFLSRRNEIPLIHFNTPIPRRHTRSAEDDSERDPLNVLKPRARMTPAPASCSQELPSAEDNSPM ASDPLGVVRGGRVNTHAGGTGPEGCRPFAKFIVDHHHHHH
內(nèi)毒素水平Less than 0.1 ng/µg (1 IEU/µg) as determined by LAL test.
Accession #Q9GZV9
性能
背景Fibroblast Growth Factor 23 (FGF-23) is a secreted protein that belongs to the heparin-binding growth factors family. FGF-23 is expressed in osteogenic cells, particularly during phases of active bone remodeling. FGF family members possess broad mitogenic and cell survival activities, involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth, and invasion. FGF-23 regulates homeostasis of phosphate and vitamin-D metabolism. FGF-23 inhibits renal tubular phosphate transport by reducing SLC34A1 levels, and negatively regulates osteoblast differentiation and matrix mineralization. FGF-23 also upregulates EGR1 expression in the presence of KL, acts directly on the parathyroid to decrease PTH secretion. Defects in FGF-23 are the cause of autosomal dominant hypophosphataemic rickets (ADHR).
溶解方法Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 μg/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
保存方法Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks. Reconstituted protein solution can be stored at 4-7°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
純度Greater than 95% as determined by reducing SDS-PAGE.

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